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Updated: Dec 25, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
[Surgical considerations for two patients with cardioembolic stroke and mobile thrombus in the left atrium appendage]
Mayuko Sakuwa1, Yuki Aozasa1, Yutaka Suto1
1Department of Neurology, Japanese Red Cross Matsue Hospital.
Insights
Anticoagulant interruption for atrial fibrillation can cause cardioembolic stroke. Optimal timing for left atrial thrombectomy after stroke depends on thrombus and infarction characteristics.
Area of Science:
- Cardiology
- Neurology
- Vascular Surgery
Background:
- Atrial fibrillation (AF) is a common arrhythmia associated with an increased risk of cardioembolic stroke.
- Left atrial appendage (LAA) thrombus is a primary source of emboli in AF patients.
- Self-interruption of anticoagulant therapy can precipitate thromboembolic events.
Abstract:
Two men (Case 1, 74 years old; Case 2, 65 years old) developed cardioembolic stroke due to self-interruption of anticoagulants for treating atrial fibrillation. They both had mobile thrombus in the left atrial appendage. In Case 1, a left atrial thrombectomy was scheduled on day 8, but infarction re-occurred on the morning of the the surgery, producing neurological sequelae. In Case 2, left atrial thrombectomy and left atrial appendage closure were performed successfully on day 8. The indication and timing of cardiac thrombectomy after the onset of cerebral infarction have not been standardized, and they seem to differ among individuals. Therefore, in the future, the optimal timing of left atrial thrombectomy should be decided based on the size and morphology of the left atrial thrombus, the size of the cerebral infarction and the presence or absence of hemorrhagic infarction.
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