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Updated: Dec 25, 2025
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Culturing and Manipulation of O9-1 Neural Crest Cells
Published on: October 9, 2018
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Metabolic Reprogramming Promotes Neural Crest Migration via Yap/Tead Signaling
Debadrita Bhattacharya1, Ana Paula Azambuja1, Marcos Simoes-Costa1
1Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
Developmental Cell
|April 4, 2020
Summary
Cancer cells exhibit the Warburg effect, enhanced aerobic glycolysis. This study reveals neural crest cells use aerobic glycolysis to promote migration and development, a mechanism reactivated in cancer.
Area of Science:
- Cellular metabolism
- Developmental biology
- Cancer research
Background:
- The Warburg effect, enhanced glycolysis in cancer, is linked to metastasis.
- Its role in normal embryonic development remains unclear.
- Neural crest cells are migratory stem cells crucial for vertebrate development.
Purpose of the Study:
- To investigate the role of metabolic remodeling in neural crest cell behavior.
- To understand how aerobic glycolysis influences embryonic development.
- To explore the link between developmental Warburg effect and cancer.
Main Methods:
- Analysis of metabolic changes in neural crest cells during embryonic development.
- Investigating the impact of increased glycolytic flux on signaling pathways.
- Studying the regulation of epithelial-to-mesenchymal transition.
Main Results:
- Neural crest cells exhibit aerobic glycolysis before delamination.
- Increased glycolytic flux enhances Yap/Tead signaling.
- This signaling cascade drives epithelial-to-mesenchymal transition for cell migration.
Conclusions:
- Aerobic glycolysis is a regulated developmental mechanism in neural crest cells.
- Metabolic shifts can trigger gene regulatory circuits controlling cell behavior.
- The Warburg effect is a conserved developmental process aberrantly reactivated in cancer.
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