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Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging
L M Erofeeva1, M V Mnikhovich2
1Research Institute of Human Morphology, Moscow, Russia. gystology@mail.ru.
Bulletin of Experimental Biology and Medicine
|April 6, 2020
Summary
Aging significantly alters human mesenteric lymph nodes, leading to reduced immune cell function and impaired lymph flow. These changes suggest a decline in immune surveillance and potential autoimmune complications with age.
Area of Science:
- Immunology
- Gerontology
- Anatomy
Background:
- The human mesenteric lymph nodes play a crucial role in immune surveillance of the gastrointestinal tract.
- Aging is associated with complex changes in immune function, termed immunosenescence.
Purpose of the Study:
- To investigate the structural and functional alterations in human mesenteric lymph nodes during the aging process.
- To understand the impact of these changes on immune cell populations and lymph node function.
Main Methods:
- Morphometric analysis of human mesenteric lymph node tissues.
- Immunohistochemical staining to identify specific cell populations (e.g., Ki-67, CD4).
Main Results:
- Observed development of fibrous connective tissue and fragmentation of lymphoid parenchyma.
- Absence of lymphoid follicles with germinal centers and decreased lymphocyte proliferation (Ki-67 negative).
- Depletion of CD4+ T helper cells in the paracortical zone and accumulation of plasma cells and eosinophils.
Conclusions:
- Aging leads to significant structural and functional degradation of mesenteric lymph nodes.
- These changes compromise immune cell regulation, potentially contributing to autoimmune processes and reduced lymph filtration capacity.
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