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Functional imaging in ectopic Cushing syndrome.

Seda Grigoryan¹, Anca M Avram², Adina F Turcu³

¹Department of Internal Medicine, Michigan State University, East Lasing.

Current Opinion in Endocrinology, Diabetes, and Obesity

|April 7, 2020

Summary

This summary is machine-generated.

[Ga]-DOTATATE imaging shows promise for locating small ectopic adrenocorticotropic hormone (ACTH)-secreting tumors causing Cushing syndrome. This functional imaging helps identify primary and metastatic sources missed by conventional methods.

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Area of Science:

Endocrinology
Nuclear Medicine
Oncology

Background:

Ectopic adrenocorticotropic hormone (ACTH)-secreting tumors cause Cushing syndrome, often presenting as fulminant forms.
These tumors are frequently small and difficult to detect with conventional imaging.
[Ga]-DOTATATE is a functional imaging agent approved for neuroendocrine tumors.

Purpose of the Study:

To review the performance of [Ga]-DOTATATE imaging in localizing ectopic ACTH-secreting tumors.
To assess its utility in identifying primary and metastatic sources of ectopic Cushing syndrome (ECS).

Main Methods:

Review of literature on [Ga]-DOTATATE performance in ECS.
Focus on functional imaging for neuroendocrine tumor detection.
Analysis of [Ga]-DOTATATE's role in identifying small, ectopic ACTH sources.

Main Results:

[Ga]-DOTATATE imaging demonstrates high, though variable, resolution for detecting ECS sources.
It has successfully identified primary and metastatic ectopic ACTH-secreting lesions missed by other modalities.
Data is emerging due to the recent clinical introduction of [Ga]-DOTATATE and low ECS prevalence.

Conclusions:

[Ga]-DOTATATE is a valuable tool for localizing ectopic ACTH-secreting tumors.
It significantly impacts patient care by improving the detection of elusive ECS sources.
Further data will clarify its full diagnostic performance in ECS.