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Serum uric acid level and subclinical left ventricular dysfunction: a community-based cohort study.
Koki Nakanishi1, Masao Daimon1,2, Yuriko Yoshida1
1Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
ESC Heart Failure
|April 8, 2020
Summary
Elevated serum uric acid (SUA) is linked to subclinical left ventricular (LV) dysfunction in the general population. This finding suggests that assessing LV global longitudinal strain (GLS) may offer prognostic insights for individuals with high SUA levels.
Area of Science:
- Cardiology
- Biochemistry
- Diagnostic Imaging
Background:
- Serum uric acid (SUA) is a marker of oxidative stress and poor prognosis in heart failure.
- The relationship between SUA and subclinical left ventricular (LV) dysfunction remains unevaluated in the general population.
- Subclinical LV dysfunction precedes overt cardiac disease and impacts long-term outcomes.
Purpose of the Study:
- To investigate the association between serum uric acid (SUA) levels and subclinical left ventricular (LV) dysfunction.
- To determine if elevated SUA is an independent predictor of abnormal LV global longitudinal strain (GLS) in individuals without known heart disease.
Main Methods:
- A cohort of 1175 general population participants underwent cardiovascular health assessments.
- Speckle-tracking echocardiography was used to measure LV global longitudinal strain (GLS).
- Statistical analyses examined the association between SUA (continuous and quartile) and abnormal LVGLS, adjusting for confounders.
Main Results:
- The prevalence of abnormal LVGLS was highest in the upper quartile of SUA.
- Elevated SUA, as a continuous variable, was significantly associated with abnormal LVGLS (aOR, 1.26 per 1 mg/dL; P = 0.008).
- The highest quartile of SUA independently predicted abnormal LVGLS (aOR, 2.28; P = 0.020) after full adjustment.
Conclusions:
- Elevated serum uric acid (SUA) is independently associated with subclinical left ventricular (LV) dysfunction in the general population.
- LV global longitudinal strain (GLS) assessment may provide prognostic value in individuals with elevated SUA, even without overt cardiac disease.
- These findings highlight SUA as a potential risk marker for early-stage cardiac abnormalities.
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