Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two-dimensional Dirac semimetal OD-BC<sub>3</sub> as an ultrahigh-performance anode for Li-, Na-, and K-ion batteries.

Physical chemistry chemical physics : PCCP·2026
Same author

In-Situ Grafting Strategy Enables Functional Separator for Advanced Lithium-Sulfur Batteries.

Small (Weinheim an der Bergstrasse, Germany)·2024
Same author

Osteoclast-Driven Polydopamine-to-Dopamine Release: An Upgrade Patch for Polydopamine-Functionalized Tissue Engineering Scaffolds.

Journal of functional biomaterials·2024
Same author

Theoretical design of rhombohedral-stacked MoS<sub>2</sub>-based ferroelectric tunneling junctions with ultra-high tunneling electroresistances.

Physical chemistry chemical physics : PCCP·2024
Same author

Bridge-oxygen bonding modulates Ru single atoms for peroxymonosulfate activation: Importance of high-valent Ru species and <sup>1</sup>O<sub>2</sub>.

Journal of colloid and interface science·2024
Same author

First-principles investigation of in-plane anisotropies in XYTe<sub>4</sub> monolayers with X = Hf, Zr, Ti and Y = Si, Ge.

Physical chemistry chemical physics : PCCP·2022

Related Experiment Video

Updated: Dec 24, 2025

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

8.8K

Perfluorocarbon-based O2 nanocarrier for efficient photodynamic therapy.

Huamin Hu1, Xuefeng Yan, Hui Wang

  • 1Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA. wyou@unc.edu.

Journal of Materials Chemistry. B
|April 8, 2020
PubMed
Summary

This study developed perfluorocarbon-based polymer micelles to enhance photodynamic therapy (PDT) by delivering oxygen. The novel formulation improved singlet oxygen generation and PDT efficacy while reducing cell toxicity.

More Related Videos

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.4K
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.5K

Related Experiment Videos

Last Updated: Dec 24, 2025

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

8.8K
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.4K
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.5K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Photodynamic Therapy

Background:

  • Tumor hypoxia limits photodynamic therapy (PDT) efficiency due to oxygen requirement for singlet oxygen generation.
  • Perfluorocarbon molecules exhibit excellent oxygen-carrying capacity, similar to artificial blood.

Purpose of the Study:

  • To develop a novel nanoplatform for improving PDT efficiency by addressing tumor hypoxia.
  • To investigate the potential of perfluorocarbon-based polymer micelles for enhanced oxygen delivery to tumors.

Main Methods:

  • Preparation of polymer micelles with a perfluorocarbon core encapsulating photosensitizers and oxygen.
  • In vitro studies to assess singlet oxygen generation and cell toxicity.
  • Correlation analysis between perfluorocarbon content and therapeutic outcomes.

Main Results:

  • Increased perfluorocarbon concentration accelerated singlet oxygen generation.
  • The perfluorocarbon-enhanced formulation significantly improved PDT efficiency.
  • Reduced cell toxicity was observed with the new perfluorocarbon-based nanoplatform compared to controls.

Conclusions:

  • Perfluorocarbon-incorporated polymer micelles offer a promising strategy to overcome tumor hypoxia in PDT.
  • This nanoplatform enhances singlet oxygen production and therapeutic efficacy.
  • The formulation presents a viable option for improving PDT outcomes with reduced side effects.