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Venous thromboembolism in inflammatory bowel disease
1Department of Medicine, NewYork-Presbyterian Columbia University Medical Center, New York, NY 10032, United States.
World Journal of Gastroenterology
|April 8, 2020
Summary
Patients with inflammatory bowel disease (IBD) face higher risks of venous thromboembolism (VTE). This review examines IBD patient VTE risk factors, low prophylaxis adherence, and identifies high-risk individuals for post-discharge VTE prevention.
Area of Science:
- Gastroenterology
- Hematology
- Pharmacology
Background:
- Inflammatory bowel disease (IBD) patients exhibit elevated risk for venous thromboembolism (VTE).
- VTE in IBD is linked to significant morbidity, mortality, and poorer disease outcomes.
- Disease hypercoagulability arises from complex interactions within coagulation, immune, and vascular systems.
Purpose of the Study:
- To review patient-specific factors influencing VTE risk in IBD.
- To explore reasons behind low VTE prophylaxis adherence in hospitalized IBD patients.
- To highlight recent data on high-risk IBD patients benefiting from post-discharge prophylaxis.
Main Methods:
- Literature review of studies on IBD and VTE.
- Analysis of clinical factors contributing to VTE risk in IBD.
- Examination of adherence rates and post-discharge prophylaxis data.
Main Results:
- Identified numerous clinical factors increasing VTE risk in IBD patients.
- Observed low adherence to VTE pharmacologic prophylaxis despite its safety.
- Highlighted a subset of high-risk IBD patients who may benefit from extended prophylaxis.
Conclusions:
- IBD patients require careful VTE risk assessment and management.
- Improving prophylaxis adherence and considering post-discharge strategies are crucial.
- Targeted interventions for high-risk IBD patients can mitigate recurrent VTE events.
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