Related Experiment Video

Updated: Dec 24, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.2K

Pathogenesis and Prevention of Worsening Axial Elongation in Pathological Myopia

Sangeethabalasri Pugazhendhi1, Balamurali Ambati2, Allan A Hunter3

  • 1PSG Institute of Medical Sciences & Research, Coimbatore, India.

Clinical Ophthalmology (Auckland, N.Z.)
|April 8, 2020
PubMed

Insights

Pediatric myopia is a growing concern. Understanding genetic and environmental factors is key to slowing its progression and preventing future eye diseases through emerging treatments.

Area of Science:

  • Ophthalmology
  • Genetics
  • Public Health

Background:

  • Pediatric myopia is a global public health issue.
  • It is linked to serious future ocular conditions like cataracts and retinal detachment.
  • The precise causes of myopia are still being researched, but genetics and environment play roles.

Purpose of the Study:

  • To review the causes and development of myopia.
  • To discuss methods for preventing myopia progression and axial elongation.
  • To explore new treatment options for myopia.

Main Methods:

  • A literature review was performed.
  • Searches of PubMed and Medline databases were conducted.
  • Keywords included "pediatric myopia," "axial elongation," "scleral remodeling," and "atropine," focusing on RCTs, systematic reviews, and meta-analyses.

Main Results:

  • Genetic factors and environmental modifications significantly impact myopia progression and related complications.
  • Current treatments improve vision and prevent amblyopia but do not halt axial elongation.
  • Emerging optical, pharmacological, and surgical treatments show promise for myopia control and ocular health preservation.

Conclusions:

  • Identifying factors influencing myopia onset and progression is crucial.
  • This understanding will aid in developing effective treatments.
  • The goal is to reduce disease burden, halt progression, and improve myopia management.
Abstract

Keywords:
atropine in the treatment of myopia (ATOM) studyaxial elongationmacular bucklemyopia maculopathiesmyopic foveoschisispediatric myopiascleral remodeling

More Related Videos

Inducement and Evaluation of a Murine Model of Experimental Myopia07:20

Inducement and Evaluation of a Murine Model of Experimental Myopia

Published on: January 22, 2019

10.4K
Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia12:25

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia

Published on: January 6, 2018

8.2K

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.1K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.0K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
890
Focusing of Light in the Eye01:16

Focusing of Light in the Eye

Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
5.0K
Accessory Structures of the Eye01:17

Accessory Structures of the Eye

Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
3.2K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.5K