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Partial tablet coating by 3D printing.

Eleni Tsintavi1, Dimitrios M Rekkas1, Ruggero Bettini2

  • 1Department of Pharmacy, National & Kapodistrian University of Athens, Panepistimiopolis Zografou, 15784 Athens, Greece.

International Journal of Pharmaceutics
|April 8, 2020
PubMed
Summary
This summary is machine-generated.

3D printing (3DP) offers novel pharmaceutical manufacturing solutions. This study used 3DP to coat tablets, successfully tuning drug release profiles for methyl-levodopa hydrochloride and acyclovir by adjusting coating parameters.

Keywords:
3D printingDesign of experimentsTablet coating

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Additive Manufacturing

Background:

  • 3D printing (3DP) is revolutionizing pharmaceutical manufacturing, enabling on-demand production and personalized medicine.
  • Challenges include customizing drug release and combining multiple active pharmaceutical ingredients (APIs) in single dosage forms.

Purpose of the Study:

  • To investigate the use of semi-solids 3D printing for partially coating tablets.
  • To tune the release profiles of hydrophilic (methyl-levodopa hydrochloride) and lipophilic (acyclovir) APIs.
  • To explore the impact of coating parameters on drug release without altering core tablet composition.

Main Methods:

  • Utilized a semi-solids 3D printer to apply a glyceride coating (Precirol ATO 5) to tablets.
  • Employed experimental design techniques to systematically modify coating parameters.
  • Investigated the effects of percentage of tablet surface coated, number of coating layers, and coated sides on API release.

Main Results:

  • Successfully achieved distinct dissolution profiles for both methyl-levodopa hydrochloride and acyclovir.
  • Demonstrated that coating percentage, layer number, and coated sides are key parameters for controlling API release.
  • Identified a non-Fickian release mechanism irrespective of the API's physicochemical properties.

Conclusions:

  • Semi-solids 3D printing provides a versatile platform for modulating drug release through precise control of tablet surface coating.
  • This approach offers a promising strategy for developing customized drug delivery systems with tailored release kinetics.
  • The ability to fine-tune release profiles using simple coating modifications enhances the potential of 3DP in pharmaceutical product development.