Related Experiment Video

Updated: Dec 24, 2025

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
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Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry

Published on: July 13, 2019

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BK polyomavirus: virus-cell interactions, host immune response, and viral pathogenesis

Simon Mazalrey1, Dorian Mc Ilroy1, Céline Bressollette-Bodin2

  • 1EA 4271 Immunovirologie et polymorphisme génétique, Université de Nantes, 1, rue Gaston Veil, 44000 Nantes, France.

Virologie (Montrouge, France)
|April 9, 2020
PubMed

Insights

BK polyomavirus (BKPyV) causes persistent infections and can lead to serious conditions in immunocompromised patients, especially kidney transplant recipients. Understanding the immune response is crucial for identifying at-risk individuals due to limited treatment options.

Area of Science:

  • Virology
  • Immunology
  • Transplantation

Background:

  • BK polyomavirus (BKPyV) establishes persistent infections and is an opportunistic pathogen.
  • It causes severe pathology in immunosuppressed individuals, particularly kidney and stem cell transplant recipients.
  • Understanding BKPyV pathogenesis is challenging due to asymptomatic primary infections and lack of animal models.

Purpose of the Study:

  • To elucidate the physiopathology of BKPyV infections.
  • To understand the antiviral immune response in BKPyV infection.
  • To identify high-risk patients for severe BKPyV-associated disease.

Main Methods:

  • Review of recent literature on BKPyV-host interactions.
  • Analysis of antiviral immune responses in kidney transplant patients.
  • Investigation of viral physiopathology and clinical manifestations.

Main Results:

  • Progress has been made in understanding virus-cell interactions.
  • Antiviral immune response characteristics are becoming clearer, especially in kidney transplant patients.
  • Identifying patients at high risk for severe infection is an ongoing challenge.

Conclusions:

  • Further research into BKPyV infection is vital for clinical management.
  • Understanding the immune response is key to managing BKPyV in transplant recipients.
  • Current management relies on immunosuppression modulation due to limited therapies.
Keywords:
BK polyomavirusimmune responserenal transplantation

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