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Aggregation induced emission-based fluorescent nanoparticles: fabrication methodologies and biomedical applications.
Xiqi Zhang1, Xiaoyong Zhang, Lei Tao
1Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing, 100084, China. weiyen@tsinghua.edu.cn sychyzhang@126.com.
Journal of Materials Chemistry. B
|April 9, 2020
Summary
Novel fluorescent nanoparticles (FNPs) offer enhanced brightness and photostability for advanced medical diagnostics. These aggregation-induced emission (AIE)-based FNPs show promise for drug delivery and imaging applications.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Materials Science
Background:
- Conventional molecular probes have limitations in brightness and photostability.
- Nanoscale platforms offer advantages for drug delivery and medical imaging.
- Aggregation-Induced Emission (AIE) phenomenon provides unique optical properties.
Purpose of the Study:
- To review recent advancements in AIE-based fluorescent nanoparticles (FNPs).
- To discuss fabrication methods for AIE-based FNPs.
- To summarize the biomedical applications of AIE-based FNPs.
Main Methods:
- Literature review of AIE-based FNP research from 2007-2013.
- Discussion of non-covalent and covalent fabrication strategies.
- Analysis of reported biomedical applications.
Main Results:
- AIE-based FNPs exhibit superior brightness and photostability.
- Various fabrication techniques enable tailored FNP properties.
- AIE-FNPs demonstrate potential in imaging, drug delivery, and diagnostics.
Conclusions:
- AIE-based FNPs represent a significant advancement in bioprobe technology.
- These nanoparticles offer versatile platforms for biomedical applications.
- Further research into AIE-FNPs promises to revolutionize medical diagnostics and therapeutics.
