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Disulfide-crosslinked albumin hydrogels.

Yuling Sun1, Yanbin Huang

  • 1Key Laboratory of Advanced Materials (MOE), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China. yanbin@tsinghua.edu.cn.

Journal of Materials Chemistry. B
|April 9, 2020
PubMed
Summary

Albumin hydrogels, created using the protein

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Albumin is a clinically safe biomaterial with high functionalization potential.
  • Developing novel albumin-based materials is crucial for advanced biomedical applications.

Purpose of the Study:

  • To create disulfide-crosslinked albumin hydrogels utilizing albumin's intrinsic thiol groups.
  • To investigate the swelling and erosion behaviors of these hydrogels in various aqueous environments.
  • To demonstrate the potential of these hydrogels in drug delivery applications.

Main Methods:

  • Synthesis of disulfide-crosslinked albumin hydrogels from albumin's thiol groups.
  • Evaluation of hydrogel swelling and erosion in solutions with and without denaturants (urea, guanidinium).

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  • Investigation of inter-to-intramolecular disulfide exchange mechanism.
  • Assessment of injectability and doxorubicin release for drug delivery potential.

    • Main Results:

    • Albumin hydrogels exhibited normal swelling in denaturant solutions but showed erosion in non-denaturant solutions.
    • A proposed mechanism of inter-to-intramolecular disulfide exchange explains the observed swelling behaviors.
    • The hydrogels demonstrated injectability through narrow needles.
    • Doxorubicin release studies confirmed the potential for drug delivery applications.

    Conclusions:

    • Disulfide-crosslinked albumin hydrogels possess unique swelling and erosion properties.
    • These albumin hydrogels are injectable and suitable for controlled drug release.
    • Albumin hydrogels represent a promising biomaterial for advanced therapeutic applications.