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Genetic Characterization and Risk Stratification of Acute Myeloid Leukemia.

Fatemeh Pourrajab1,2, Mohamad Reza Zare-Khormizi3, Azam Sadat Hashemi4

  • 1Department of Biochemistry and Molecular Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Cancer Management and Research
|April 11, 2020
PubMed
Summary

Acute myeloid leukemia (AML) involves molecular changes crucial for prognosis and novel therapies. Identifying specific biomarkers aids in patient classification and personalized medicine approaches for AML treatment.

Keywords:
AMLacute myeloid leukemiagenetic characterizationrisk stratification

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Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Acute myeloid leukemia (AML) is the most prevalent acute leukemia in adults.
  • AML pathophysiology involves cytogenetic abnormalities, gene mutations, and aberrant gene expression, impacting epigenetic and genetic signatures.

Purpose of the Study:

  • To review molecular alterations in AML.
  • To discuss risk stratification based on molecular markers.
  • To explore therapeutic decision-making informed by these alterations.

Main Methods:

  • Literature review focusing on molecular changes in AML.
  • Analysis of prognostic and predictive value of biomarkers.
  • Examination of novel therapeutic targets and personalized medicine strategies.

Main Results:

  • Molecular changes in AML serve as critical prognostic and predictive markers.
  • Cytogenetic abnormalities and molecular alterations are key biomarkers for AML prognosis and treatment selection.
  • Identifying driver gene mutations is essential for developing targeted therapies.

Conclusions:

  • A panel of multiple biomarkers is crucial for AML patient classification and individualized treatment.
  • Establishing algorithms using biomarkers facilitates personalized medicine in AML.
  • Understanding molecular alterations guides risk stratification and therapeutic decisions in AML.