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Updated: Dec 24, 2025

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
Published on: April 6, 2022
Glucose level determination in single cells in their satiety and starvation states using an enzymatic functional
Dandan Wang1, Guohua Qi2, Ya Zhou1
1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. ydjin@ciac.ac.cn and University of Science and Technology of China, Hefei, Anhui 230026, China.
Abstract:
A cytochrome c (Cyt c)-modified glass nanopore sensing platform was constructed to sensitively detect glucose in single cells based on changes in the ionic current rectification (ICR) of the system. A difference in glucose content between single H8 and HeLa cells in their satiety or starvation states was clearly able to be detected using this method.

