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Updated: Dec 24, 2025

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Hidden phase-retrieved fluorescence tomography.

Daniele Ancora, Diego Di Battista, Asier Marcos Vidal

|April 15, 2020

Summary

This summary is machine-generated.

This study introduces tomography through disorder, using light scattering in opaque materials to reconstruct hidden fluorescent samples. This novel approach exploits light

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Area of Science:

Optics and Photonics
Biomedical Imaging
Computational Science

Background:

Fluorescence tomography is a key technique for structural and functional imaging.
Light scattering in opaque media typically hinders imaging, but advances in disordered photonics offer new possibilities.
Opaque materials can function as autocorrelation lenses, enabling light focusing and imaging.

Purpose of the Study:

To propose and demonstrate a novel imaging technique: tomography through disorder.
To reconstruct a three-dimensional fluorescent sample concealed behind an opaque barrier.
To adapt the fundamental Fourier-slice theorem for imaging in scattering media.

Main Methods:

Development of a modified Fourier-slice theorem tailored for disordered photonics.
Utilizing the light-scattering properties of opaque materials as a feature for imaging.
Reconstruction of a hidden 3D fluorescent sample using the proposed tomography approach.

Main Results:

Successful demonstration of 3D fluorescent sample reconstruction through an opaque medium.
Validation of the modified Fourier-slice theorem for imaging in scattering environments.
Exploitation of light scattering, previously a challenge, as an enabling factor in tomography.

Conclusions:

Tomography through disorder offers a new paradigm for imaging objects hidden by scattering media.
This method leverages advances in disordered photonics to overcome traditional imaging limitations.
The adapted Fourier-slice theorem provides a robust framework for reconstructing fluorescent samples in challenging optical conditions.