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I, 3. The enteric nervous system and infectious diarrhea
Ove Lundgren1, Lennart Svensson2
1Department of Physiology, Sahlgrenska Academy, Göteborg University, Box 432, S-405 30, Göteborg, Sweden.
Perspectives in Medical Virology
|April 15, 2020
Summary
The enteric nervous system (ENS) plays a key role in regulating intestinal secretions and diarrhea. Understanding ENS involvement in conditions like rotavirus diarrhea offers new therapeutic targets for secretory disorders.
Area of Science:
- Gastroenterology
- Neurogastroenterology
- Physiology
Background:
- The enteric nervous system (ENS) is a complex neural network within the gastrointestinal tract.
- The ENS regulates various gut functions, including secretion and motility.
- Secretory states of the small intestine are critical in maintaining fluid and electrolyte balance.
Purpose of the Study:
- To review the anatomy and physiology of the ENS.
- To discuss the role of the ENS in intestinal secretory states.
- To highlight the ENS involvement in rotavirus (RV) diarrhea and potential therapeutic strategies.
Main Methods:
- Literature review of experimental evidence on ENS involvement in gut secretion.
- Focus on cholera toxin-induced secretion as a model.
- Analysis of ENS role in rotavirus (RV) diarrhea pathophysiology.
Main Results:
- Experimental evidence supports the ENS's involvement in cholera toxin-induced secretion.
- The ENS plays a significant role in the pathophysiology of rotavirus (RV) diarrhea.
- Understanding ENS mechanisms in diarrhea opens new avenues for drug development.
Conclusions:
- The ENS is a crucial regulator of intestinal secretory states.
- Targeting the ENS offers potential for novel pharmacological treatments for diarrhea.
- Further research into ENS-pharmacology can lead to effective therapies for secretory disorders.
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