Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Variability of the pattern electroretinogram.

K Holopigian1, J Snow, W Seiple

  • 1Department of Ophthalmology, NYU Medical Center, NY 10016.

Documenta Ophthalmologica. Advances in Ophthalmology
|September 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical endpoints special session, ISCEV 2025, Utrecht.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same author

A Perovskite-Graphene Device for X-ray Detection.

Carbon·2023
Same author

Odderon Exchange from Elastic Scattering Differences between pp and pp[over ¯] Data at 1.96 TeV and from pp Forward Scattering Measurements.

Physical review letters·2021
Same author

Measurement of the Effective Weak Mixing Angle in pp[over ¯]→Z/γ^{*}→ℓ^{+}ℓ^{-} Events.

Physical review letters·2018
Same author

Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron.

Physical review letters·2018
Same author

Evidence for a B_{s}^{0}π^{±} State.

Physical review letters·2016
Same journal

The relationship between foveal anatomy and retinal function in oculocutaneous albinism.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Early onset primary angle closure and foveal retinoschisis associated with a pseudo-homozygous CRB1 pathogenic variant.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Bilateral perifoveal macular ischemia in non-proliferative Duchenne muscular dystrophy-associated retinopathy: a case report.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Association between dynamic pupil parameters and corneal sub-basal nerve plexus morphology.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Structure-function relationship between handheld photopic negative response and macular GCIPL thickness in chronic optic neuropathy.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Clinical course of a patient with PRSS56-associated nanophthalmos (isolated microphthalmia) and uveal effusion syndrome.

Documenta ophthalmologica. Advances in ophthalmology·2026
See all related articles

High variability in pattern electroretinogram (PERG) recordings can obscure results. While some recording adjustments reduced variability, intersession differences remained significant, cautioning against its clinical application.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Visual Electrophysiology

Background:

  • Parametric properties of the pattern electroretinogram (PERG) have yielded conflicting results.
  • This variability may stem from inherent amplitude recording inconsistencies.

Purpose of the Study:

  • To investigate the sources of variability in pattern electroretinogram (PERG) recordings.
  • To determine if modifying stimulus or recording conditions can reduce this variability.

Main Methods:

  • Assessed variability within a single stimulus condition, noting ranges from 30% to 67% of the mean.
  • Modified stimulus conditions to observe effects on variability.
  • Adjusted recording conditions, including rejection band, number of sweeps, and reference electrode placement (ear vs. temple).

Related Experiment Videos

Main Results:

  • High intra-condition variability (30-67%) potentially masked spatial frequency tuning.
  • Changing stimulus conditions did not significantly reduce variability.
  • Optimized recording conditions (narrower rejection band, more sweeps, ear reference electrode) decreased within-session variability.
  • Intersession variability remained high despite recording condition improvements.

Conclusions:

  • High inherent variability in PERG recordings poses challenges for data interpretation.
  • Optimized recording parameters can reduce within-session variability.
  • Significant intersession variability necessitates caution in clinical use and data evaluation.
  • Further research is needed to standardize PERG to improve its clinical utility.