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ASSOCIATION OF DUODENAL EOSINOPHILIC INFILTRATE WITH HELICOBACTER PYLORI INFECTION, BUT NOT WITH FUNCTIONAL DYSPEPSIA
Carine Leite1, Luiz Edmundo Mazzoleni1,2, Diego de Mendonça Uchoa3
1Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Pós-Graduação em Ciências em Gastroenterologia e Hepatologia, Porto Alegre, RS, Brasil.
Arquivos De Gastroenterologia
|April 16, 2020
Summary
Helicobacter pylori infection increases duodenal eosinophils, but this eosinophilic infiltration is not linked to functional dyspepsia. This study clarifies the relationship between H. pylori and duodenal eosinophils.
Area of Science:
- Gastroenterology
- Immunology
- Microbiology
Background:
- The link between Helicobacter pylori infection and duodenal eosinophilic infiltration remains unclear.
- Increased duodenal eosinophils are associated with functional dyspepsia.
Purpose of the Study:
- To investigate the impact of H. pylori infection on duodenal eosinophil counts.
- To determine the role of duodenal eosinophilic infiltrate in functional dyspepsia.
Main Methods:
- Patients were classified as H. pylori positive or negative.
- Functional dyspepsia patients (cases) and asymptomatic controls were enrolled.
- Upper endoscopy with biopsies for H. pylori testing and duodenal eosinophil counting was performed.
Main Results:
- H. pylori positive individuals showed significantly higher duodenal eosinophil counts (median 13.2) compared to H. pylori negative individuals (median 8.1).
- No significant difference in duodenal eosinophil counts was found between functional dyspepsia cases (median 11.9) and controls (median 12.6).
Conclusions:
- Duodenal eosinophil count is associated with H. pylori infection.
- Duodenal eosinophil count was not associated with functional dyspepsia in this study.
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