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Primary Localized Conjunctival Amyloidosis Presenting Corneal Whorl-like Opacity Patterns
Vijay K Sharma1, Manisha Agarwal2, Aman Tyagi1
1Department of Ophthalmology, Army Hospital Research and Referral, New Delhi, India; and.
Cornea
|April 18, 2020
Summary
Primary localized conjunctival amyloidosis can present unusually with corneal whorl-like opacities. This case highlights a rare manifestation of conjunctival amyloidosis involving the cornea.
Area of Science:
- Ophthalmology
- Pathology
Background:
- Primary localized conjunctival amyloidosis (PLCA) typically affects the conjunctival fornix and lids.
- Corneal involvement in PLCA is uncommon, with distinct clinical presentations.
Observation:
- A 35-year-old male presented with bilateral corneal whorl-like opacity patterns.
- The patient was diagnosed with primary localized conjunctival amyloidosis.
Findings:
- Histopathology confirmed amyloid deposition in the conjunctiva and limbus.
- Negative genetic testing ruled out gelatinous drop-like corneal dystrophy.
- Systemic workup excluded secondary systemic amyloidosis.
Implications:
- This case expands the known clinical spectrum of primary localized conjunctival amyloidosis.
- Corneal opacities can be an initial presenting sign of PLCA.
- Early recognition is crucial for appropriate diagnosis and management.
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