Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleiotropy01:33

Pleiotropy

43.0K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.0K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

17.7K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.7K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.2K
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

7.3K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
7.3K
Incomplete Dominance01:43

Incomplete Dominance

29.5K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
29.5K
Human Genetics01:28

Human Genetics

1.3K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Analysis of the burden of non-alcoholic fatty liver disease-related cirrhosis in China from 1990 to 2021].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2026
Same author

[Application of artificial intelligence in preoperative planning of dental implants: technical status, clinical validation and future prospects].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2026
Same author

[Characteristics and survival analysis of 60 cases of primary diffuse large B-cell lymphoma of the breast].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2026
Same author

[Prediction of recurrence-free survival of T1 glottic carcinoma based on enhanced CT anterior commissure invasion and tumor volume].

Zhonghua yi xue za zhi·2026
Same author

[Mediated effect of sleep disorders on the association between shift work and major depressive symptoms].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2026
Same author

[Short-term efficacy and influencing factors of systemic antibiotics as an adjunct to mechanical periodontal therapy for stages Ⅲ/Ⅳ periodontitis].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2026

Related Experiment Video

Updated: Dec 23, 2025

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.7K

[Association between GPX1 gene polymorphisms and noise-induced hearing loss].

J Y Li1, J Jiao2, G S Chen3

  • 1National Center for Occupational Safety and health, NHC, Beijing 102308, China.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal of Industrial Hygiene and Occupational Diseases
|April 21, 2020
PubMed
Summary

Genetic variations in the Glutathione peroxidase 1 gene (GPX1) are linked to increased risk of noise-induced hearing loss (NIHL). Specific GPX1 polymorphisms may identify individuals susceptible to hearing damage from occupational noise exposure.

Keywords:
GPX1 geneGenetic variabilityHearing loss, NoiseNoise-Induced hearing lossSNPSingle nucleotide polymorphism

More Related Videos

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

12.2K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.3K

Related Experiment Videos

Last Updated: Dec 23, 2025

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.7K
Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

12.2K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.3K

Area of Science:

  • Genetics
  • Occupational Health
  • Audiology

Background:

  • Noise-induced hearing loss (NIHL) is a significant occupational health concern.
  • Genetic factors are increasingly recognized as contributing to individual susceptibility to NIHL.
  • The Glutathione peroxidase 1 (GPX1) gene plays a role in cellular antioxidant defense, potentially influencing protection against noise damage.

Purpose of the Study:

  • To investigate the association between genetic polymorphisms in the GPX1 gene and the risk of developing NIHL.
  • To identify specific GPX1 single nucleotide polymorphisms (SNPs) that may confer susceptibility to noise-induced hearing damage.

Main Methods:

  • A nested case-control study was conducted on noise-exposed steel factory workers.
  • 392 cases of NIHL were matched with 392 controls based on gender, age, and noise exposure duration.
  • Two GPX1 SNPs (rs1987628) were genotyped, and their association with NIHL was analyzed using logistic regression.

Main Results:

  • Both genotyped SNPs were in Hardy-Weinberg equilibrium.
  • The rs1987628 polymorphism showed a statistically significant association with NIHL risk under codominant and dominant models.
  • Individuals with the rs1987628 GA genotype had a higher NIHL risk (aOR=1.803), as did those with GA+AA genotypes (aOR=1.762).

Conclusions:

  • Genetic polymorphism in the GPX1 gene is suggested to be a potential genetic susceptibility factor for NIHL.
  • The rs1987628 SNP in GPX1 may increase an individual's risk of developing hearing loss due to noise exposure.
  • These findings highlight the role of genetic predisposition in occupational NIHL.