Unfolded Protein Response (UPR) Controls Major Senescence Hallmarks
Corinne Abbadie1, Olivier Pluquet1
1University of Lille, CNRS, Inserm, CHU Lille, Institute Pasteur de Lille, UMR 9020-UMR-S1277 - Cancer Heterogeneity, Plasticity and Resistance to Therapies, F-59000 Lille, France.
Trends in Biochemical Sciences
|April 21, 2020
Summary
Cellular senescence, a stress response, may be linked to the unfolded protein response (UPR). This study explores how UPR signaling might contribute to the key features of senescence.
Area of Science:
- Cellular Biology
- Molecular Biology
- Stress Response Mechanisms
Background:
- Cellular senescence is a complex state characterized by a stress response phenotype.
- The precise mechanisms governing the acquisition and maintenance of senescence remain incompletely understood.
Purpose of the Study:
- To investigate the potential role of the unfolded protein response (UPR) in cellular senescence.
- To explore the UPR as a signaling platform associated with major senescence hallmarks.
Main Methods:
- This study presents a theoretical argument and synthesis of existing literature.
- No new experimental data was generated; it is a conceptual review.
Main Results:
- The unfolded protein response (UPR) is proposed as a potential signaling platform in senescence.
- UPR signaling pathways may be intrinsically linked to the development and persistence of senescence.
Conclusions:
- The unfolded protein response (UPR) may serve as a crucial signaling nexus for cellular senescence.
- Further research is warranted to elucidate the direct mechanistic links between UPR and senescence hallmarks.
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