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Effects of short term experimental diabetes on brain serotonin metabolism
G Atienza1, M Aldegunde, R Durán
1Departamento de Fisiología, Facultad de Biología, Santiago de Compostela, Spain.
Revista Espanola De Fisiologia
|September 1, 1988
Abstract:
Serotonin metabolism was studied in several brain regions of control and Streptozotocin-treated male Wistar rats. After induction of diabetes, the animals were killed at 24 hours. Concentrations of brain tryptophan show a generalized increase in all brain regions, being only significant in medulla-pons. Serotonin levels do not change, while 5-HIAA concentrations, as well as the ratio 5-HIAA/5-HT, show significant increases in medulla-pons and mid-brain.