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Updated: Dec 23, 2025
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
Impact of bone events on survival in solitary bone plasmacytoma
Geovanne Pedro Mauro1, Pedro Pereira Neffá2, Rosangela Correa Villar3,4
1Department of Radiology and Oncology - Radiotherapy - Faculdade de Medicina da Universidade de São Paulo. Avenida Doutor Arnaldo, 155 - Cerqueira César, 01255-000 Sao Paulo - SP, Brazil.
Background:
Although much studied in multiple myeloma, bone events (BE) can also cause important morbidity in bone plasmacytoma patients. To our knowledge, the effect of BE on overall survival (OS) and progression to multiple myeloma free-survival (MPFS) also has never been studied.
Patients And Methods:
Fifty-nine patients treated from 2008 to 2017 were retrospectively assessed. All patients had histological proof of disease and were treated with radical radiotherapy (RT). Available clinical information for at least 6 months follow-up or until death had to be available. BE were described as one of the following events in the index bone: fractures, osteomyelitis, chronic pain, surgery or loss of limb function after RT.
Results:
Mean age at diagnosis was 57.3 years (18-80); most male (67.8%). Mean OS, bone event free-survival (BEFS), local progression-free survival (LPFS) and MPFS were 41, 36, 37 and 19 months, respectively. There were 15 deaths. BEFS (p = 0.008) and age>55y (p = 0.044) were associated with MPFS. Only BEFS correlated with OS (p = 0.029). BE was independently associated with both MPFS and OS in multivariate analysis.
Conclusion:
BE and survival end-points were correlated. BE should be investigated in prospective trials.
