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Targeting autophagy-related protein kinases for potential therapeutic purpose

Honggang Xiang1, Jifa Zhang1, Congcong Lin1

  • 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.

Acta Pharmaceutica Sinica. B
|April 24, 2020
PubMed

Keywords:
4E-BP1, eukaryotic translation initiation factor 4E-binding proteinAKT1, AKT serine/threonine kinase 1AMBRA1, autophagy/beclin-1 regulator 1AMPK, AMP-activated protein kinaseARF, auxin response factor geneATG, autophagy-related proteinAutophagyAutophagy-related kinaseCaMKK2, calcium/calmodulin-dependent protein kinase kinase 2DAPK, death associated protein kinaseFIP200, FAK family kinase-interacting protein of 200 kDaGAP, GTPase-activating proteinGO, gene ontologyGSK3α, glycogen synthase kinase 3 alphaHMGB1, high mobility group protein B1Human disease therapyJNK1, C-Jun N-terminal kinaseLC3, microtubule-associated protein 1 light chain 3LKB1, serine/threonine-protein kinase stk11LPS, lipopolysaccharideLRRK2, leucine rich repeat kinase 2PD, Parkinson's diseasePI, phosphatidylinositolPI3 kinase, phosphoinositide 3-kinasePI3P, phosphatidylinositol triphosphatePIM2, proviral insertion in murine lymphomas 2PINK1, PTEN-induced putative kinase 1PIP2, phosphatidylinositol-4,5-bisphosphatePKACα, a protein kinase cAMP-activated catalytic subunit alphaPKCα, protein kinase C alpha typePKD1, polycystin-1PPIs, protein–protein interactionsPROTAC, proteolysis targeting chimerasPTMs, post-translational modificationsPhosphorylationProtein kinasesRheb, the RAS homolog enriched in brainSmall-molecule kinase inhibitors/activatorsTAK1, transforming growth factor activated kinase-1TFEB, transcription factor EBTNBC, triple-negative breast cancerTSC1/2, tuberous sclerosis complex proteins 1/2ULK complex, ULK1–mATG13–FIP200–ATG101 complexULK1, unc-51-like kinase 1UVRAG, ultraviolet resistance-associated genemTOR, mammalian target of rapamycinmTORC1, mammalian target of rapamycin complex 1

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