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Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
Published on: February 1, 2019
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Development of new self-assembled cationic amino liposomes for efficient gene delivery
Yihang Wu1, Yue Xiong, Ling Wang
1School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, P.R. China. gaolq@mail.sysu.edu.cn glqustc@gmail.com dengwb5@mail.sysu.edu.cn.
Biomaterials Science
|April 24, 2020
Abstract:
A library of 83 structurally diverse cationic amino liposomes is rationally designed and parallelly synthesized for the transfection of plasmid DNA and siRNA. Our designed self-assembled liposomes not only exhibit excellent transfection efficiency in HEK 293T cells and mouse embryonic stem cells, but also show low cytotoxicity.
