[Psychopathology of the schizophrenic defect (creation of an integrated model of negative changes)]

An integrative model of schizophrenic defect is offered. The model presumes the negative changes to extend over all the levels of psychic activity, though in uneven manner, rather than be confined to a distinct sphere. In 200 schizophrenic patients the defect had a complicated structure integrating the negative changes of schizoid and pseudoorganic types. Extreme variants of integration of schizoid and pseudoorganic changes can be regarded as two distinct defect types with prevailing personality deformations (combination of verschroben-type changes with personality level decreasing) and the fall in psychic activiity (combination of pseudobradyphrenia with schizoid deficit-type changes).