Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hand hygiene01:23

Hand hygiene

5.3K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
5.3K
Bacterial Signaling01:30

Bacterial Signaling

39.8K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
39.8K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

843
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
843
Surface Membrane Barriers01:18

Surface Membrane Barriers

2.5K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
2.5K
Antimicrobial Proteins01:23

Antimicrobial Proteins

12.8K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
12.8K
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

6.6K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic Effects of Black Seed Oil, Fresh Clove Extracts, and Amoxicillin Against Bacterial Skin Pathogens: An In Vitro Experimental Study.

Cureus·2026
Same author

Metabolomic-based promising technique for fruit-based natural products analysis.

Food chemistry: X·2026
Same author

Antioxidant Potential of Polyphenolic Compounds, Sources, Extraction, Purification and Characterization Techniques: A Focused Review.

Food science & nutrition·2025
Same author

Comment on: "A systematic review and meta-analysis: the role of potassium-competitive acid blockers in endoscopy-negative reflux disease."

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2025
Same author

Letter to the Editor on "Association Between Kidney Stones and Subsequent Risk of Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-Analysis".

Urology·2025
Same author

<i>Syzygium aromaticum</i> extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities.

Frontiers in chemistry·2025

Related Experiment Video

Updated: Dec 23, 2025

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

3.8K

"Smart" Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI).

Zehra Edis1, Samir Haj Bloukh2, May Reda Ibrahim1

  • 1College of Pharmacy and Health Sciences, Department of Pharmaceutical Sciences, Ajman University, PO Box 346, Ajman, UAE.

Pharmaceutics
|April 25, 2020
PubMed
Summary
This summary is machine-generated.

New silver nanoparticles (AgNP) synthesized with trans-cinnamic acid and povidone-iodine show potent antimicrobial activity. These novel materials, especially when coated on Polyglycolic Acid sutures, offer a promising strategy to prevent surgical site infections caused by resistant pathogens.

Keywords:
antimicrobial activitybiodegradablenatural cinnamon extractpolyiodidespovidone iodinesilver nanoparticlessurgical site infectionsurgical suturetrans-cinnamic acid

More Related Videos

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties
11:19

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Published on: May 10, 2018

10.6K
Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.7K

Related Experiment Videos

Last Updated: Dec 23, 2025

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

3.8K
Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties
11:19

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Published on: May 10, 2018

10.6K
Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.7K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Microbiology

Background:

  • Antibiotic resistance poses a significant global health threat, necessitating the development of novel antimicrobial strategies.
  • Natural and plant-derived compounds, combined with nanotechnology, offer promising avenues for combating resistant pathogens.
  • Biosynthesized silver nanoparticles (AgNP) exhibit inherent antimicrobial properties that can be enhanced through synergistic combinations.

Purpose of the Study:

  • To synthesize and characterize novel AgNP formulations incorporating trans-cinnamic acid (TCA) and povidone-iodine (PI).
  • To evaluate the antimicrobial efficacy of these new AgNP compounds and their application as coatings for Polyglycolic Acid (PGA) sutures.
  • To investigate the potential of these materials in preventing surgical site infections (SSI) caused by a range of microorganisms.

Main Methods:

  • Synthesis of AgNP using TCA and natural cinnamon bark extract (Cinn), with and without PI.
  • Coating of biodegradable PGA sutures with the synthesized AgNP formulations.
  • Antimicrobial activity testing using disc and agar-well diffusion methods against 10 reference microbial strains.
  • Characterization of synthesized compounds using DLS, UV-Vis, FT-IR, Raman, XRD, SEM, and EDS.

Main Results:

  • TCA-AgNP-PI and Cinn-AgNP-PI demonstrated broad-spectrum antimicrobial activity.
  • AgNP-coated PGA sutures showed significant potential for preventing microbial growth.
  • TCA-AgNP-PI exhibited superior antimicrobial efficacy compared to Cinn-AgNP-PI both in vitro and on coated sutures.
  • Comprehensive characterization confirmed the composition and structure of the novel AgNP materials.

Conclusions:

  • Novel hybrid AgNP materials, particularly TCA-AgNP-PI, are effective broad-spectrum antimicrobial agents.
  • These AgNP formulations represent promising candidates for coating medical devices like PGA sutures to prevent SSIs.
  • Hybrid materials leveraging synergistic antimicrobial actions offer a forward-looking approach to combatting resistant microorganisms.