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From Sequence-Defined Macromolecules to Macromolecular Pin Codes.

Joshua O Holloway1, Filip Van Lijsebetten1, Nezha Badi1

  • 1Polymer Chemistry Research group (PCR) Centre of Macromolecular Chemistry (CMaC) Department of Organic and Macromolecular Chemistry Faculty of Sciences Ghent University Krijgslaan 281-S4bis Ghent 9000 Belgium.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 25, 2020
PubMed
Summary
This summary is machine-generated.

Chemically encoded information in polymers can be encrypted and decrypted using dynamic covalent bonds. This novel method offers a secure, reversible approach for product tagging and anti-counterfeiting applications.

Keywords:
1,2,4‐triazoline‐3,5‐dionechemical encryptionmulticomponent reactionssequence‐defined macromolecules

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Area of Science:

  • Polymer Chemistry
  • Supramolecular Chemistry
  • Organic Synthesis

Background:

  • Dynamic covalent chemistry enables the creation of responsive materials.
  • Information encryption in polymers is crucial for security and anti-counterfeiting.
  • Existing methods for information erasure and readout often involve irreversible degradation.

Purpose of the Study:

  • To develop a novel method for creating sequence-defined oligomers with encrypted information.
  • To demonstrate the reversible encryption and decryption of chemically encoded information.
  • To explore the application of these macromolecules as coded product tags.

Main Methods:

  • Utilizing multicomponent reactions and thermoreversible addition of 1,2,4-triazoline-3,5-diones (TADs) to indole substrates.
  • Employing heat-induced random reshuffling of TAD-indole bonds for information encryption.
  • Using 1D electrospray ionization-mass spectrometry (ESI-MS) for information decryption.

Main Results:

  • Successfully synthesized dynamic sequence-defined oligomers with a chemically written pin code.
  • Demonstrated reversible encryption and decryption of the encoded information through controlled heating.
  • Showcased the potential of these macromolecules for anti-counterfeiting by coating them onto polymer materials.

Conclusions:

  • The developed strategy offers a precise and reversible method for encoding and decoding information in polymers.
  • This approach advances information security in materials, moving beyond irreversible degradation methods.
  • The findings highlight a promising application in developing sophisticated anti-counterfeiting technologies.