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Cell Culture Based in vitro Test Systems for Anticancer Drug Screening
Kristina V Kitaeva1, Catrin S Rutland2, Albert A Rizvanov1,2
1Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
Frontiers in Bioengineering and Biotechnology
|April 25, 2020
Summary
Selecting appropriate in vitro tumor models is crucial for effective preclinical anticancer drug screening. This improves drug development efficiency by reducing costs and time, leading to better clinical trial outcomes.
Area of Science:
- Oncology
- Pharmacology
- Biotechnology
Background:
- Preclinical anticancer drug screening faces challenges with poor in vitro-in vivo-clinical trial correlation.
- Accurate in vitro tumor models are vital for efficient drug development and cost reduction.
Purpose of the Study:
- To review and describe current high-tech in vitro tumor models for preclinical anticancer drug screening.
- To highlight the importance of selecting appropriate models for improving drug development pipelines.
Main Methods:
- Review of existing literature on in vitro tumor models.
- Description of various models including 2D, 3D, microfluidic systems, Boyden's chamber, and 3D bioprinting.
Main Results:
- Various in vitro models (2D, 3D, microfluidics, bioprinting) are used in preclinical drug screening.
- Each model possesses unique characteristics influencing research outcomes.
Conclusions:
- Advancements in in vitro screening systems are essential for accelerating the development of novel anticancer agents.
- Improved model selection enhances the reliability of preclinical data, benefiting researchers and clinicians.
