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Updated: Dec 23, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
[Three independent melanomas over a span of 2 years in a 31-year-old man-a case report]
1Abteilung für Dermatologie, Venerologie, Allergologie, Bundeswehrzentralkrankenhaus Koblenz, Rübenacher Str. 170, 56068, Koblenz, Deutschland. matthias1huebner@bundeswehr.org.
Abstract:
We present the case of a 31-year-old soldier who developed three independent melanomas in only 2 years. We saw two mucosal melanomas and one nodular melanoma of the scalp. The last one led to a cerebral metastasis during the course of the follow-up. After complete resection and under ongoing immunotherapy with nivolumab, there was no progression of disease until December 2019. The Karnofsky index remained at 100% and there were no side effects of therapy. Besides fair skin type, no other risk factors for the development of melanomas were identified, even after performing genetic analysis.

