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COVID-19: an update on diagnostic and therapeutic approaches

Mahalaxmi Iyer1, Kaavya Jayaramayya1, Mohana Devi Subramaniam2

  • 1Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641-043, India.

BMB Reports
|April 28, 2020
PubMed

Insights

The COVID-19 pandemic necessitates rapid development of diagnostics and therapeutics. This review covers updated diagnostic methods and treatments, including repurposed drugs like hydroxychloroquine and convalescent plasma, for controlling SARS-CoV-2.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has prompted urgent global efforts to develop effective diagnostics and treatments.
  • Current strategies involve limiting viral replication and managing immune-mediated tissue damage.

Discussion:

  • This review examines advancements in specimen collection, efficient diagnostic tools, and therapeutic interventions for COVID-19.
  • It highlights the repurposing of existing drugs, such as chloroquine/hydroxychloroquine, and the use of convalescent plasma (CP) as potential treatments.

Key Insights:

  • Repurposed therapeutics, including hydroxychloroquine and convalescent plasma, have demonstrated clinical effectiveness against COVID-19.
  • Rapid development of diagnostic algorithms is crucial for identifying and containing the virus.
  • A multifaceted approach combining diagnostics, therapeutics, and control measures is essential.

Outlook:

  • Further research is needed to fully understand the impact of diagnostics and therapeutics on COVID-19 outcomes.
  • Continued investigation is vital for the development of novel vaccines and drugs to combat the virus.
  • Global collaboration is key to addressing the ongoing challenges posed by the pandemic.

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