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Updated: Dec 23, 2025
Integration Free Derivation of Human Induced Pluripotent Stem Cells Using Laminin 521 Matrix
Published on: July 7, 2017
Karolinska Institutet Human Embryonic Stem Cell Bank
Heather Main1, Mona Hedenskog1, Ganesh Acharya1
1Department of Clinical Sciences, Intervention and Technology, Karolinska Insitutet, 17177, Stockholm, Sweden; Gynecology and Reproductive Medicine, Karolinska University Hospital, 14186 Stockholm, Sweden.
Abstract:
The Karolinska Institutet Human Embryonic Stem Cell Bank (KI Stem Cell Bank) was established at KI, Stockholm, Sweden, when the first human embryonic stem cell (hESC) line was derived by Professor Hovatta and colleagues in 2002. Since then, the bank has grown to include 60 hESC lines. From the very beginning the aim of the bank has been derivation of hESC lines suitable for clinical use. Step by step progress has been made towards this goal, including removal of xeno components, establishment of chemically defined conditions and Good Manufacturing Practice (GMP) compliancy. Today our bank includes such clinical grade hESC line, KARO1, derived and banked according to GMP guidelines. Many of the hESC lines in the bank have been distributed to the scientific community and are deposited in the Stockholm Medical Biobank available for research on collaborative basis.
