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Updated: Dec 23, 2025

Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
Published on: May 26, 2023
Optimizing DME Treatment With Decreased Injection Frequency Using Long-Term Steroid Implants.
Intravitreal corticosteroid implants offer an effective, long-term treatment for diabetic macular edema (DME), overcoming the logistical challenges of monthly anti-vascular endothelial growth factor (VEGF) injections.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Pharmacology
Background:
- Anti-vascular endothelial growth factor (VEGF) agents are standard for diabetic macular edema (DME).
- Monthly anti-VEGF injections present logistical challenges for patients.
- Limited efficacy of anti-VEGF in clinical practice necessitates alternative treatments.
Purpose of the Study:
- To evaluate intravitreal corticosteroid implants as a long-term treatment for DME.
- To compare the efficacy and pharmacokinetics of corticosteroid implants versus anti-VEGF agents.
Main Methods:
- Review of recent large-scale, randomized, controlled trials.
- Analysis of pharmacokinetic advantages in vitrectomized eyes.
- Assessment of side effect profiles and management.
Main Results:
- Intravitreal corticosteroid implants demonstrate long-term efficacy in DME treatment.
- Implants block multiple inflammatory factors, offering sustained action (months to years).
- Corticosteroid implants maintain bioavailability and efficacy in vitrectomized eyes, unlike anti-VEGF agents.
Conclusions:
- Intravitreal corticosteroid implants provide a convenient and efficacious long-term DME treatment.
- Manageable side effects (cataracts, ocular hypertension) require monitoring.
- Corticosteroid implants are a valuable alternative to frequent anti-VEGF injections for DME.
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