Online Scavenging of Trace Analytes in Complex Matrices for Fast Analysis by Carbon Dioxide Bubbling Extraction...

Carbon dioxide (CO₂) microbubbles can selectively enrich organic solutes from sea spray aerosols. Common bubbling extractions are normally followed by off-line separation/detection through methods such as mass spectrometry, chromatography, and spectroscopy. However, it is necessary to establish extractions with online separation and identification systems to improve efficiency and minimize sample loss. In this study, CO₂ is used to form microbubbles in the sample solution, and trace analytes in the solution are transported to the gas phase by bubble bursting. Analytes at the liquid-gas interface are directly released into the trapping device, followed by thermal desorption for gas chromatography-mass spectrometry. For polycyclic aromatic hydrocarbons, the dependence of the extraction efficiency on various parameters has been analyzed. The method reported here provides high efficiency and minimizes the loss of trace volatiles with a better signal strength and signal-to-noise ratio than other gases. These features make the proposed method a rapid method to detect and quantify volatile/semivolatile analytes in complex liquid matrices. In addition to the preconcentration of organics, metal ions, and inorganic anions, a noticeable decrease of metal-organic compounds in the aqueous solution was shown for the first time. We finally propose a simple model of chemical partitioning in CO₂ bubbling extraction of liquid samples for guiding online monitoring of trace analytes in real-world samples.