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Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
Published on: January 9, 2019
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Intrasellar gangliocytoma with multiple immunoreactivities
Shozo Yamada1,2,3,4, Lucia Stefaneanu1,2,3,4, Kalman Kovacs1,2,3,4
1Division of Neurosurgery (SY, TA), Toranomon Hospital, 2-2- 2, Toranomon, Minato-Ku, Tokyo 105, Japan.
Endocrine Pathology
|May 3, 2020
Summary
This study details a rare intrasellar gangliocytoma, a brain tumor, that did not cause hormonal imbalances. The tumor produced various peptides but lacked clinical effects, highlighting unusual peptide combinations in gangliocytomas.
Area of Science:
- Neuroscience
- Endocrinology
- Pathology
Background:
- Intrasellar gangliocytomas are rare tumors located in the pituitary gland.
- These tumors can sometimes be associated with hormonal dysfunctions (endocrinopathy).
Purpose of the Study:
- To report a rare case of intrasellar gangliocytoma presenting without any endocrinopathy.
- To investigate the peptide expression profile of this specific tumor.
Main Methods:
- The tumor was surgically removed using a transsphenoidal approach.
- Immunohistochemical analysis was performed to detect peptide expression within the tumor cells.
Main Results:
- The intrasellar gangliocytoma was successfully resected.
- Immunoreactivities for vasoactive intestinal peptide (VIP), galanin, alpha-subunit, somatostatin, and serotonin were identified in the tumor cells.
- Despite the presence of these peptides, the patient did not exhibit any clinical signs of endocrinopathy.
Conclusions:
- Gangliocytomas can express unusual combinations of biologically active peptides.
- The expression of these peptides does not invariably lead to clinical abnormalities or hormonal imbalances.
