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Related Experiment Video

Updated: Dec 22, 2025

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Poorly differentiated thyroid carcinoma.

Bin Xu¹, Ronald Ghossein¹

¹Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, U.S.

Seminars in Diagnostic Pathology

|May 4, 2020

Summary

Poorly differentiated thyroid carcinoma (PDTC) presents a diagnostic challenge due to varying criteria. This review clarifies histology, diagnostic criteria, and prognostic factors for this aggressive thyroid cancer.

Keywords:

BRAF Insular carcinoma Poorly differentiated thyroid carcinoma RAS Turin proposal

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Area of Science:

Endocrinology
Oncology
Pathology

Background:

Poorly differentiated thyroid carcinoma (PDTC) is an aggressive thyroid cancer with intermediate prognosis.
Diagnostic criteria for PDTC lack universal consensus, leading to classification challenges.

Purpose of the Study:

To review the histology, diagnostic criteria, prognostic factors, and molecular profile of PDTC.
To provide a practical guide for understanding and diagnosing PDTC.

Main Methods:

Review of existing literature on PDTC histology and diagnostic criteria.
Comparison of the Memorial Sloan Kettering Cancer Center (MSKCC) criteria and the Turin proposal.
Summary of prognostic factors and molecular characteristics.

Main Results:

Two main sets of criteria exist: MSKCC (mitotic index and/or necrosis) and Turin proposal (growth pattern, nuclear features, and mitotic index/necrosis/convoluted nuclei).
Disagreement persists regarding the precise definition and application of these criteria.
Prognostic factors and molecular profiles are being elucidated to better understand PDTC behavior.

Conclusions:

Standardizing PDTC diagnostic criteria is crucial for consistent patient management and research.
Further research into prognostic factors and molecular alterations will improve therapeutic strategies for PDTC.
This review offers a comprehensive overview to aid clinicians and researchers in managing PDTC.