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Recurrent circuit dynamics underlie persistent activity in the macaque frontoparietal network.

Eric Hart1, Alexander C Huk1

  • 1Center for Perceptual Systems, Department of Neuroscience, Department of Psychology, The University of Texas at Austin, Austin, United States.

Elife
|May 8, 2020
PubMed
Summary

Neurons in the lateral intraparietal area (LIP) and frontal eye fields (FEF) show persistent activity. We recorded neural ensembles to reveal strong recurrent excitation and differing connectivity between LIP and FEF.

Keywords:
FEFGLMLIPcouplingneurosciencepersistent activityrhesus macaqueworking memory

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Systems Neuroscience

Background:

  • Neurons in the lateral intraparietal area (LIP) and frontal eye fields (FEF) show persistent activity during delayed oculomotor response tasks.
  • This activity is crucial for maintaining behaviorally relevant information.
  • Existing computational models lack sufficient circuit-level data from primates.

Purpose of the Study:

  • To investigate the circuit-level dynamics of persistent activity in the frontoparietal network.
  • To provide empirical data to inform computational models of neural persistence.

Main Methods:

  • Simultaneous ensemble recordings of neurons in LIP and FEF in macaques.
  • Performance of a memory-guided saccade task.
  • Application of a population encoding model to analyze neural activity and connectivity.

Main Results:

  • Identified strong and symmetric long-timescale recurrent excitation between LIP and FEF.
  • Discovered stronger local functional connectivity within LIP compared to FEF.
  • Observed longer network and intrinsic timescales for many LIP neurons.

Conclusions:

  • Revealed reciprocal multi-area circuit dynamics in the frontoparietal network during persistent activity.
  • Suggested that differences in connectivity may stem from attractor network dynamics.
  • Provided foundational data for quantitative comparisons with theoretical models of neural persistence.