Related Experiment Video
Updated: Feb 13, 2026
14:40
Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
Published on: October 27, 2020
20.1K
Active gaze behavior organizes V1 activity in freely-moving marmosets
Jingwen Li1, Vikram Pal Singh1, Jude F Mitchell2
1Cortical Systems & Behavior Lab, Department of Psychology, UCSD, La Jolla, CA 92093.
Biorxiv : the Preprint Server for Biology
|February 12, 2026
Summary
Primate vision in the primary visual cortex (V1) is actively shaped by natural gaze behavior. Eye movements like gaze shifts and fixations modulate neural activity, demonstrating a link between natural vision and brain responses.
Area of Science:
- Neuroscience
- Primate Vision Research
Background:
- Primates heavily rely on vision for environmental interaction.
- Most primate visual cortex studies use head-fixed models, limiting understanding of natural active vision.
Purpose of the Study:
- To investigate how the primate visual system supports active vision in freely moving animals.
- To explore neural activity in the primary visual cortex (V1) during natural gaze behavior.
Main Methods:
- Utilized a head-mounted eye-tracking system in freely moving marmosets.
- Simultaneously recorded activity from ensembles of single V1 neurons.
Main Results:
- Primate neural activity in V1 is tightly driven by visual input and organized by gaze behavior.
- Gaze-related responses were abolished without visual input.
- Gaze shifts suppressed V1 responses, while fixation enhanced them, linked to visual input.
Conclusions:
- Defined V1 dynamics linking natural gaze behavior and stimulus-driven responses in freely moving primates.
- Established freely moving paradigms for studying real-world visual processing during ethologically relevant behaviors.
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