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Updated: Dec 21, 2025

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
Published on: December 15, 2023
Hepatitis B: Immunization and Impact on Natural History and Cancer Incidence
1Department of Gastroenterology, Renai Branch, Taipei City Hospital, No. 10, Sec. 4, Renai Rd, Taipei 10629, Taiwan; Department of Psychology, National Chengchi University, Taipei, Taiwan.
Abstract:
Enhancing host immunity by vaccination to prevent hepatitis B virus (HBV) infection remains the most important strategy for global control of hepatitis B. Currently, 187 countries have in place infant hepatitis B vaccination programs. Hepatitis B surface antigen prevalence has decreased to less than 1% in children after successful implementation of universal HBV vaccination in newborns. The incidence of primary liver cancer in children, adolescents, and young adults has drastically decreased to near zero in birth cohorts receiving hepatitis B vaccination. Elimination of chronic hepatitis B by 2030 is not a mission impossible.
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