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[Doxycycline Sensitive Two-Promoter Integrator Based on the TET-ON 3G Transactivator]

Yu M Khodarovich1,2, D D Rakhmaninova1, A M Barishnikova1

  • 1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, 117997 Russia.

Molekuliarnaia Biologiia
|May 12, 2020
PubMed
Summary

Researchers developed a synthetic genetic circuit, a two-promoter integrator, that activates gene expression only when two specific cancer promoters are highly active. This system shows promise for targeted gene transcription in tumor cells.

Keywords:
gene chainsgene therapyintegratoroncologysynthetic biologytransactivator

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