Related Experiment Video
Updated: Dec 21, 2025

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
Published on: May 10, 2024
A complicated chinese herbal medicine nephrotoxicity
Haider Ali Omer Mohamed1, Osama Mirghani Osman2, Husaam Haider Ali3
1Department of Medicine, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Chinese herbal medicine can cause severe kidney damage, a condition known as Chinese herbal nephropathy. This case highlights unusual symptoms like metabolic acidosis and Stokes-Adams syndrome in a patient with renal impairment.
Area of Science:
- Nephrology
- Toxicology
- Integrative Medicine
Background:
- Chinese herbal medicine (CHM) is a prevalent global practice.
- Adverse outcomes associated with CHM use are increasingly reported.
- Understanding CHM's toxicological profile is crucial for patient safety.
Observation:
- A 43-year-old woman presented with significant renal impairment.
- The patient exhibited metabolic acidosis, hypernatremia, and hypokalemia.
- Stokes-Adams syndrome was also a notable clinical feature.
Findings:
- The constellation of symptoms pointed towards Chinese herbal nephropathy.
- The observed clinical presentation was atypical compared to previously documented cases.
- This case underscores the potential for severe, uncharacteristic adverse effects from CHM.
Implications:
- Clinicians should maintain a high index of suspicion for CHM-induced nephrotoxicity.
- Further research is needed to identify specific nephrotoxic agents within CHM.
- Enhanced monitoring and reporting of adverse events related to CHM are essential.
Related Concept Videos
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Chronic Kidney Disease III: Interprofessional Care
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Kidney Transplant II: Surgical Procedure
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Chronic Kidney Disease II: Clinical Manifestations

