Related Experiment Video
Updated: Dec 21, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
Revenant: a database of resurrected proteins.
Matias Sebastian Carletti1, Alexander Miguel Monzon1,2, Emilio Garcia-Rios3
1Departamento de Ciencia y Tecnología, CONICET, Universidad Nacional de Quilmes, Roque Saenz Peña 182, Bernal, B1876BXD, Buenos Aires, Argentina.
Revenant is a database of 84 resurrected proteins from extinct organisms, aiding evolutionary research. This resource provides structural and biochemical data for ancient proteins, enabling new scientific insights.
Area of Science:
- Biochemistry
- Evolutionary Biology
- Bioinformatics
Background:
- Resurrected proteins offer insights into evolutionary history.
- Databases are crucial for organizing and accessing such specialized data.
Purpose of the Study:
- To present Revenant, a curated database of resurrected proteins.
- To facilitate research on ancient protein functions and evolution.
Main Methods:
- Manual curation of bibliographic data for protein information.
- Ancestral sequence reconstruction (computational) combined with wet-lab synthesis and expression.
- Database development with timeline browsing and detailed annotation.
Main Results:
- Revenant contains 84 manually curated resurrected proteins.
- Proteins range from 4200 to 3500 million years ago and 8.8 to 6.3 million years ago.
- Each entry includes structural, biochemical, and biophysical data.
Conclusions:
- Revenant serves as a valuable resource for studying ancient proteins.
- The database supports research into protein stability, function origins, and ancient metabolisms.
More Related Videos
05:08Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
Published on: July 8, 2025
07:38Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
Published on: April 11, 2019
Related Concept Videos
Conservation of Protein Domains Over Different Proteins
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
Conservation of Protein Domains
Protein Families
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks
Protein Organization
The primary structure of a protein is its amino acid sequence....