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Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.

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Related Experiment Video

Updated: Dec 21, 2025

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

Ephrin-B2 paces neuronal production in the developing neocortex.

Anthony Kischel¹, Christophe Audouard¹, Mohamad-Ali Fawal¹

¹Centre de Biologie Intégrative (CBI), Centre de Biologie du Développement (CBD), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, 31062, Toulouse, France.

BMC Developmental Biology

|May 15, 2020

Summary

This summary is machine-generated.

Ephrin-B2 signaling regulates the timing of neocortical projection neuron production during development. Despite transient changes, neural progenitors adapt to ensure stereotypical neuron numbers, highlighting developmental plasticity.

Keywords:

Eph:ephrin signaling Mouse Neocortex Neural progenitors Neurogenesis

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Published on: January 12, 2015

Area of Science:

Neuroscience
Developmental Biology
Cell Signaling

Background:

Mammalian cerebral cortex development involves precise temporal generation of projection neurons.
Mechanisms controlling neocortical projection neuron timing and numbers are not fully understood.

Purpose of the Study:

To investigate the role of ephrin-B2 in regulating neurogenesis timing and neuronal production during neocortex development.

Main Methods:

Utilized conditional mutant embryos for ephrin-B2.
Administered synthetic ephrin-B2 via in utero injection.
Employed genetic approaches to study ephrin-B2's action on neural progenitors.

Main Results:

Ephrin-B2 acts via juxtacrine signaling on neural progenitors to control differentiation.
Loss of ephrin-B2 caused a transient delay in neurogenesis.
Acute stimulation of Eph signaling led to a transient increase in neuronal production.
Perinatal neuron numbers recovered in both loss and gain of function scenarios.

Conclusions:

Ephrin-B2 plays a crucial role in regulating the tempo of embryonic neurogenesis in the neocortex.
Neural progenitors exhibit adaptive plasticity to maintain stereotypical neuron production.