Related Experiment Video
Updated: Dec 21, 2025
Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice
Published on: January 19, 2018
Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor
Le Yu1, Jun Feng Zhang2, Mingle Li3
1College of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China. yingzhou@ynu.edu.cn and Department of Chemistry, Korea University, Seoul 02841, Korea. jongskim@korea.ac.kr.
Abstract:
We report a novel fluorescent molecular conjugate, V-M1, enabling an accurate visualization of tumor tissues. The emission wavelength of V-M1 exceeds 650 nm, which is well within the near-infrared therapeutic window. Tumor accumulation of this cationic dye allows the visualization of cancerous cells as a function of mitochondrial viscosity.
