Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Visualizing cellular G-quadruplexes with a bioinspired chemiluminescent probe.

Nucleic acids research·2026
Same author

The presence and impact of G-quadruplexes in plant chloroplast DNA.

BMC plant biology·2026
Same author

High-throughput measurement and prediction of the i-motif DNA stability landscape.

Nucleic acids research·2026
Same author

Archaeal G-quadruplexes: a novel model for understanding unusual DNA/RNA structures across the tree of life.

Nucleic acids research·2026
Same author

Designing an ecofriendly catalyst for a sustainable use of water resources.

National science review·2026
Same author

Pentanucleotide guanine-rich WGGGW repeats, including CANVAS AGGGA repeats, form a variety of noncanonical structures.

Nucleic acids research·2026
Same journal

Preclinical evaluation of novel FGFR2-targeting peptide probes for PET imaging and intraoperative navigation in gastric Cancer.

Bioorganic chemistry·2026
Same journal

New functionalized silica nanoparticles (SiNPs) as a potential daunorubicin delivery platform: an in vitro proof-of-concept evaluation.

Bioorganic chemistry·2026
Same journal

Aloin suppresses cancer cell growth via autophagy-promoted NEDD8 de-NEDDylation to target GPX4 for ferroptosis induction.

Bioorganic chemistry·2026
Same journal

Design, synthesis, and biological evaluation of novel selenium-matrine hybrid compounds as topo I -targeted anticancer agents.

Bioorganic chemistry·2026
Same journal

Discovery of novel tyrosinase-inhibitory peptides FW and LAW from bullfrog (Lithobates catesbeianus) muscle protein: In silico screening, inhibition kinetics, gastrointestinal stability, and anti-melanogenic efficacy in zebrafish.

Bioorganic chemistry·2026
Same journal

Tumor-targeted activatable molecular agent for synergistic chemo-photodynamic therapy.

Bioorganic chemistry·2026
See all related articles

Related Experiment Video

Updated: Dec 21, 2025

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
03:38

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction

Published on: October 6, 2022

1.8K

Phthalocyanines for G-quadruplex aptamers binding.

Jéssica Lopes-Nunes1, Josué Carvalho1, Joana Figueiredo1

  • 1CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.

Bioorganic Chemistry
|May 16, 2020
PubMed
Summary
This summary is machine-generated.

This study explores zinc(II) phthalocyanine (ZnPc) derivatives as potential ligands for G-quadruplex (G4) structures, like the AS1411 aptamer. Certain ZnPc derivatives show promise in stabilizing G4 structures and exhibiting selective anti-cancer activity.

Keywords:
Biophysical characterizationG-quadruplex aptamersPhthalocyanines

More Related Videos

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping
05:32

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping

Published on: May 12, 2023

1.7K
Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor
09:33

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Published on: March 21, 2018

10.2K

Related Experiment Videos

Last Updated: Dec 21, 2025

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
03:38

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction

Published on: October 6, 2022

1.8K
Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping
05:32

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping

Published on: May 12, 2023

1.7K
Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor
09:33

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Published on: March 21, 2018

10.2K

Area of Science:

  • Medicinal Chemistry
  • Biochemistry
  • Nanotechnology

Background:

  • G-quadruplex (G4) structures, such as the AS1411 aptamer, are therapeutic targets.
  • Modifying AS1411 with alternative nucleobases and backbones can enhance its properties.
  • Zinc(II) phthalocyanine (ZnPc) derivatives are investigated as potential G4 ligands due to structural similarities.

Purpose of the Study:

  • To investigate the interaction of ZnPc derivatives with G4 AS1411 aptamer and its modified forms.
  • To evaluate the potential of ZnPc derivatives as G4 ligands for therapeutic applications.
  • To assess the antiproliferative effects of ZnPc derivatives and their complexes on cancer cells.

Main Methods:

  • Biophysical techniques (CD, NMR, gel electrophoresis) were used to study interactions.
  • Molecular docking was employed to predict binding sites of ZnPc derivatives.
  • Cell viability assays were performed to determine cytotoxicity and antiproliferative effects.

Main Results:

  • CD experiments indicated structural changes and multiple binding modes of ZnPc derivatives with G4 structures.
  • ZnPc 2 and ZnPc 4 demonstrated significant stabilization of the AT11 G4 structure.
  • Molecular docking suggested specific binding preferences of ZnPc 3 and ZnPc 4 to the AT11 G4 ends.
  • ZnPc 3 and its complexes showed potent cytotoxicity against cervical cancer cells with no toxicity to normal cells.

Conclusions:

  • ZnPc derivatives can effectively interact with and stabilize G4 structures.
  • ZnPc derivatives, particularly ZnPc 3, show promise as selective anti-cancer agents.
  • These findings support the development of ZnPc derivatives as therapeutic G4 ligands.