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Biohybrid robotics with living cell actuation.

Lingyu Sun1, Yunru Yu2, Zhuoyue Chen2

  • 1Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 210008 Nanjing, China. lingyunsun@nju.edu.cn and Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Clinical College of Xuzhou Medical University, Nanjing 210008, P. R. China and Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China. fye@iphy.ac.cn and State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 210096 Nanjing, China. yjzhao@seu.edu.cn.

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Summary

Biohybrid robots integrate living cells with soft materials to mimic nature. These advanced robots show promise in drug delivery, bioimaging, and tissue engineering applications.

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Area of Science:

  • Robotics
  • Biotechnology
  • Materials Science

Background:

  • Soft robots are increasingly designed to simulate organisms.
  • Biohybrid robots, combining living cells and soft materials, offer unique advantages for mimicking biological tissues and organs.
  • These systems are attracting significant research interest due to their potential.

Purpose of the Study:

  • To review current research on biohybrid robots.
  • To detail the components, control methods, and locomotion of these robots.
  • To highlight their biomedical applications and future prospects.

Main Methods:

  • Review of recent studies on biohybrid robots.
  • Analysis of biological actuators (e.g., contractile cells, microorganisms).
  • Examination of synthetic materials and integration techniques.

Main Results:

  • Biohybrid robots utilize diverse biological actuators.
  • Controlling methods and locomotion strategies have been clarified.
  • Key applications include drug delivery, bioimaging, and tissue engineering.

Conclusions:

  • Biohybrid robots represent a significant advancement in soft robotics.
  • Their biomedical applications are vast and promising.
  • Further research is needed to address challenges and unlock future potential.