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Epstein-Barr Virus and Thyroid Cancer
Jacqueline Fátima Martins Almeida1, Karina Colombera Peres1, Elisângela Souza Teixeira1
1Laboratory of Cancer Molecular Genetics (Gemoca), Department of Medical Clinical, Faculty of Medical Sciences, State University of Campinas (FCM-Unicamp), Campinas, SP, Brazil.
Critical Reviews in Oncogenesis
|May 19, 2020
Summary
Epstein-Barr virus (EBV), a human carcinogen, is being investigated for its role in thyroid cancer. This review explores the history of EBV and thyroid cancer to understand its potential contribution to tumor development.
Area of Science:
- Oncology
- Virology
- Pathology
Background:
- Epstein-Barr virus (EBV) is a globally prevalent herpesvirus with known carcinogenic properties, linked to lymphoid and epithelial cancers.
- EBV has been detected in thyroid tissues, particularly in autoimmune and neoplastic conditions, but its specific role in thyroid disease remains uncertain.
- Existing studies on EBV presence in thyroid cancer (TC) show highly variable results, influenced by population demographics and research methodologies.
Purpose of the Study:
- To review the historical association between Epstein-Barr virus (EBV) and thyroid cancer (TC).
- To elucidate the potential role of EBV in the development of thyroid tumors.
- To guide future research on EBV's involvement in thyroid tumorigenesis.
Main Methods:
- This is a review article, synthesizing existing literature on EBV and thyroid cancer.
- Historical data and research findings on EBV detection in thyroid specimens were analyzed.
- Methodological variations in previous studies were considered.
Main Results:
- The presence and significance of EBV in thyroid cancer are not definitively established.
- Reported prevalence of EBV in thyroid cancer varies widely across different studies and populations.
- The oncogenic potential of EBV in thyroid tumorigenesis requires further investigation.
Conclusions:
- The exact role of Epstein-Barr virus (EBV) in thyroid cancer development is still unclear and requires more research.
- Further studies employing standardized methodologies are needed to confirm or refute EBV's contribution to thyroid tumorigenesis.
- Understanding EBV's role could offer new insights into thyroid cancer prevention and treatment strategies.
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