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IL-15 Expression Pattern in Atopic Dermatitis.

Hélène Karlen¹, Shida Yousefi², Hans-Uwe Simon^2,3

¹Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

International Archives of Allergy and Immunology

|May 19, 2020

Summary

This summary is machine-generated.

Interleukin-15 (IL-15) is elevated in atopic dermatitis (AD) skin, appearing in keratinocytes, dendritic cells, macrophages, and fibroblasts. This suggests IL-15 could be a therapeutic target for AD.

Keywords:

Atopic dermatitis Dendritic cell Fibroblast Interleukin 15 Keratinocyte

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Area of Science:

Immunology
Dermatology
Cell Biology

Background:

Interleukin-15 (IL-15) is a cytokine crucial for immune cell stimulation, implicated in various inflammatory and autoimmune conditions.
Atopic dermatitis (AD) is a prevalent inflammatory skin disorder associated with a type 2 immune response.

Purpose of the Study:

To investigate the expression and localization patterns of IL-15 within the skin of individuals with atopic dermatitis.
To compare IL-15 expression in lesional AD skin, nonlesional AD skin, and normal skin.

Main Methods:

Immunofluorescence staining was employed on skin biopsies from AD patients (lesional and nonlesional) and healthy controls.
Antibodies targeting IL-15 and various immune and structural cell markers (CD3, mast cell tryptase, eosinophil cationic protein, CD68, CD11b, CD1a, vimentin) were utilized.

Main Results:

Significantly higher IL-15 expression was detected in both the epidermis and dermis of AD and nonlesional AD skin compared to normal skin.
IL-15 expressing cells included keratinocytes, CD1a+ dendritic cells (DCs), CD11b+ DCs, CD68+ macrophages, and vimentin+ fibroblasts.
AD skin showed an increased relative number of IL-15 expressing CD1a+ DCs, macrophages, and fibroblasts.

Conclusions:

The expression pattern of IL-15 in atopic dermatitis skin resembles that observed in other type 2 immune diseases like eosinophilic esophagitis.
Interleukin-15 presents a potential therapeutic target for the management of atopic dermatitis.