Related Experiment Video For Carbon nanoparticles
Updated: Dec 21, 2025
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Application of carbon nanoparticles in localization of parathyroid glands during total parathyroidectomy for
Wei Li1, Bingyang Liu1, Chengxiang Shan1
1Department of General Surgery, Changzheng Hospital, Naval medical university, Shanghai, 200003, China.
Background:
Intraoperative imaging is used to address the challenges of parathyroidectomy, but no standard modality has been established. This study aimed to assess whether carbon nanoparticle injection is useful in localizing parathyroid glands (PGs) during parathyroidectomy.
Methods:
Patients who underwent total parathyroidectomy (TPTX) between September 2015 and November 2018 were included. The operative duration and intact parathyroid hormones (iPTH) were analyzed.
Results:
A total of 61 patients were included; of these, 32 with carbon nanoparticle injection (TPTX + CN group) and 29 without (TPTX group). The operative duration in the TPTX + CN group was significantly shorter (90.6 ± 21.2 vs 101.4 ± 19.4 min, P = 0.042), which is more apparent in those with normal sized PGs. For those with four enlarged PGs, iPTH levels on 1 day and 1 year postoperatively were significantly lower in the TPTX + CN group (P = 0.032 and P = 0.036, respectively).
Conclusion:
Carbon nanoparticles are useful in the identification normal sized PGs and complete resection of enlarged PGs.
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