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Weight Gain in Infants With Pierre Robin Sequence in the First Year of Life

Leo Li1, Andrew R Scott1,2,3

  • 1Tufts University School of Medicine, Boston, Massachusetts, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|May 20, 2020
PubMed

Insights

Infants with Pierre Robin sequence (PRS) show similar birth weights but slower growth rates compared to WHO standards, though weight deficits resolve by 12 months. This highlights potential growth challenges even after early airway intervention.

Area of Science:

  • Pediatric Growth and Development
  • Craniofacial Anomalies
  • Medical Interventions

Background:

  • Pierre Robin sequence (PRS) is a congenital condition characterized by micrognathia, glossoptosis, and airway obstruction.
  • Growth patterns in infants with PRS are not fully understood, particularly in comparison to established growth standards.
  • Early intervention, including surgical procedures like mandibular distraction osteogenesis, is often necessary for managing PRS-related complications.

Purpose of the Study:

  • To compare the growth trajectories of infants diagnosed with Pierre Robin sequence (PRS) against the World Health Organization (WHO) growth standards.
  • To identify potential deviations in weight gain and growth rates during the first year of life for infants with PRS.

Main Methods:

  • A retrospective case series design was employed, analyzing data from 24 infants with PRS treated between 2009 and 2017.
  • Infant weights were systematically recorded at 1- to 3-month intervals from birth to 12 months, with adjustments for prematurity.
  • The 50th percentile (P50) weight for the PRS cohort was calculated and compared to WHO growth standards.

Main Results:

  • Birth weight P50 was comparable to WHO standards for both female and male infants with PRS.
  • A significant lag in growth rate was observed, with P50 weights falling below WHO standards by month 5 for females and month 3 for males.
  • Weight deficiencies demonstrated a trend towards resolution by 12 months of age in both sexes.

Conclusions:

  • Infants with PRS may exhibit similar birth weights but experience a slower growth rate compared to healthy infants.
  • This growth lag can persist even after surgical correction of upper airway obstruction, indicating a potential systemic impact of PRS.
  • Monitoring growth trends is crucial for infants with PRS to ensure timely intervention and support for optimal development.
Abstract

Keywords:
Pierre Robin sequencecleft palategrowth curveweight gain

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